Erythropoietin in the Management of Anemia in HIV: A Review

  • Emmanuel Ifeanyi Obeagu Department of Medical Laboratory Science, Kampala International University, Uganda.
  • Getrude Uzoma Obeagu School of Nursing Science, Kampala International University, Uganda.
Keywords: Anemia, Adverse Effects, Erythropoietin, Hematopoiesis, HIV, Treatment

Abstract

Anemia is a prevalent and debilitating complication in individuals living with HIV, significantly impacting their quality of life and overall health. This review examines the potential of erythropoietin (EPO) as a therapeutic intervention for managing anemia in HIV patients. The efficacy of EPO in addressing HIV-related anemia is critically evaluated through a synthesis of existing clinical studies and trials, assessing its impact on hemoglobin levels, quality of life, and broader clinical outcomes. Safety considerations, including potential adverse effects such as thromboembolic events, hypertension, and immunomodulatory effects, are also discussed. The review concludes by addressing challenges and considerations associated with the use of EPO in the context of HIV, highlighting the need for optimal dosing, patient selection, and potential interactions with antiretroviral therapy. Lastly, future directions and research gaps are outlined, emphasizing the necessity for continued investigation to refine the application of erythropoietin in the management of anemia in HIV patients. Overall, this review provides a comprehensive synthesis of the current state of knowledge on EPO in HIV-related anemia, offering valuable insights for clinicians, researchers, and healthcare practitioners involved in the care of individuals living with HIV.

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Offie DC, Obeagu EI, Akueshi C, Njab JE, Ekanem EE, Dike PN, Oguh DN. Facilitators and barriers to retention in HIV care among HIV infected MSM attending Community Health Center Yaba, Lagos Nigeria. Journal of Pharmaceutical Research International. 2021;33(52B):10-19.

Obeagu EI, Obeagu GU, Ede MO, Odo EO, Buhari HA. Translation of HIV/AIDS knowledge into behavior change among secondary school adolescents in Uganda: A review. Medicine (Baltimore). 2023;102(49): e36599. doi: https://doi.org/10.1097/MD.0000000000036599

Herd CL. Evaluating the effects of HIV-1 infection on haematopoietic stem cell colony formation (Doctoral dissertation, University of Pretoria).2019.

Anyiam AF, Arinze-Anyiam OC, Irondi EA, Obeagu EI. Distribution of ABO and rhesus blood grouping with HIV infection among blood donors in Ekiti State Nigeria. Medicine (Baltimore). 2023;102(47): e36342. doi: https://doi.org/10.1097/MD.0000000000036342

Echefu SN, Udosen JE, Akwiwu EC, Akpotuzor JO, Obeagu EI. Effect of Dolutegravir regimen against other regimens on some hematological parameters, CD4 count and viral load of people living with HIV infection in South Eastern Nigeria. Medicine (Baltimore). 2023;102(47): e35910. doi: https://doi.org/10.1097/MD.0000000000035910

Opeyemi AA, Obeagu EI. Regulations of malaria in children with human immunodeficiency virus infection: A review. Medicine (Baltimore). 2023;102(46): e36166. doi: https://doi.org/10.1097/md.0000000000036166

Alum EU, Obeagu EI, Ugwu OPC, Samson AO, Adepoju AO, Amusa MO. Inclusion of nutritional counseling and mental health services in HIV/AIDS management: A paradigm shift. Medicine (Baltimore). 2023;102(41): e35673. doi: https://doi.org/10.1097%2FMD.0000000000035673

Aizaz M, Abbas FA, Abbas A, Tabassum S, Obeagu EI. Alarming rise in HIV cases in Pakistan: Challenges and future recommendations at hand. Health Sci Rep. 2023;6(8): e1450. doi: https://doi.org/10.1002/hsr2.1450

Obeagu EI, Obeagu GU, Obiezu J, Ezeonwumelu C, Ogunnaya FU, Ngwoke AO, Emeka-Obi OR, Ugwu OP. Hematologic Support in HIV Patients: Blood Transfusion Strategies and Immunological Considerations. APPLIED SCIENCES (NIJBAS). 2023;3(3). https://nijournals.org/hematologic-support-in-hiv-patients-blood-transfusion-strategies-and-immunological-considerations/

Obeagu EI, Ubosi NI, Uzoma G. Storms and Struggles: Managing HIV Amid Natural Disasters. Int. J. Curr. Res. Chem. Pharm. Sci. 2023;10(11):14-25. https://ijcrcps.com/pdfcopy/2023/nov2023/ijcrcps2.pdf

Obeagu EI, Obeagu GU. Human Immunodeficiency Virus and tuberculosis infection: A review of prevalence of associated factors. Int. J. Adv. Multidiscip. Res. 2023;10(10):56-62. https://ijarm.com/pdfcopy/2023/oct2023/ijarm5.pdf

Obeagu EI, Malot S, Obeagu GU, Ugwu OP. HIV resistance in patients with Sickle Cell Anaemia. Newport International Journal of Scientific and Experimental Sciences (NIJSES). 2023;3(2):56-9. https://publications.kiu.ac.ug/publication-page.php?i=hiv-resistance-in-patients-with-sickle-cell-anaemia

Alum EU, Ugwu OP, Obeagu EI, Aja PM, Okon MB, Uti DE. Reducing HIV Infection Rate in Women: A Catalyst to reducing HIV Infection pervasiveness in Africa. International Journal of Innovative and Applied Research. 2023;11(10):01-6. https://www.journalijiar.com/uploads/203_IJIAR-2534.pdf

Agarwal R. Individualizing decision-making—resurrecting the doctor-patient relationship in the anemia debate. Clinical Journal of the American Society of Nephrology. 2010;5(7):1340-1346. doi: https://doi.org/10.2215/cjn.02830310

Published
2024-03-30
How to Cite
Ifeanyi Obeagu, E., & Uzoma Obeagu, G. (2024). Erythropoietin in the Management of Anemia in HIV: A Review. International Research in Medical and Health Sciences, 6(6), 36-48. https://doi.org/10.36437/irmhs.2023.6.6.D