Adverse Reactions Incidence Rates of Covid-19 Vaccination in First and Second Doses, First Booster and Fourth Doses in General Medicine
Abstract
Background: It is not clearly known the variation in the incidence of adverse reactions during the different doses of the COVID-19 vaccine.
Objective: Determine the incidence rate of adverse COVID-19 vaccine reactions.
Emplacement: The population attended in a general medicine consultation in Toledo, Spain.
Methodology: Secondary analysis of observational, longitudinal, and prospective studies of self-reported adverse COVID-19 vaccine reactions, from February to September 2021 (first and second doses), from November 2021 to August 2022 (first booster), and from October 1, 2022 to February 28, 2023 (fourth dose; second booster).
Results: The total incidence rate of adverse reactions in the vaccinated population was higher for the first and second doses (5%), and lower for the second booster (0.4%). The figures for the first booster were intermediate between the two (2%). This pattern was maintained in people over and less than 65 years of age and by gender. The incidence rate by age was always higher in <65 years in all doses. By sex, the incidence rate was always higher in women vs. men. The total incidence rate of adverse reactions with respect to the total population attended in the general medicine practice maintained the same pattern, except in those >=65 years of age who had the same incidence in the third and fourth doses.
Conclusion: The incidence rate of adverse covid-19 vaccine reactions, both in figures with respect to the vaccinated population and with respect to the total population dependent on the general medicine consultation, has been decreasing from the first doses to the last ones. This is possibly due 1) to a real decrease in the immunogenicity of the boosters, and 2) a lower demand for this reason that entails a lower number of adverse reactions in the general practitioner's office.
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